"Literally, the word [sin] means "missing the mark", but the biblical meaning of sin is much deeper. It's not as if Adam and Eve were trying very hard to keep God's command and just missed the bull's-eye by a few degrees. No, the fact is that they were shooting in the opposite direction! They had goals and desires that were categorically opposed to what God desired for them, and so they sinned. They deliberately violated God's command, broke their relationship with him, and rejected him as their rightful Lord."
Greg Gilbert, What is the Gospel